Boemong ba sepheo sa "khabone e habeli" le phetoho e tala indastering ea leruo la liphoofolo lefatšeng ka bophara, theknoloji e nyane ea peptide trace element e fetohile sesebelisoa sa mantlha sa ho rarolla likhohlano tse peli tsa "ntlafatso ea boleng le ts'ebetso" le "ts'ireletso ea tikoloho" indastering ka litšobotsi tsa eona tsa ho monya le ho fokotsa tlhahiso. Ka ts'ebetsong ea EU "Co-additive Regulation (2024 / EC)" le ho tsebahala ha thekenoloji ea blockchain, tšimo ea liminerale tse nyenyane tse phelang li ntse li fetoha ka mokhoa o tebileng ho tloha tlhahisong ea matla ho ea ho mehlala ea saense, le ho tloha tsamaisong e pharaletseng ho ea ho latelloa ka ho feletseng. Sengoliloeng sena se sekaseka ka mokhoa o hlophisehileng boleng ba ts'ebeliso ea theknoloji e nyane ea peptide, se kopanya tataiso ea leano la ho rua liphoofolo, liphetoho tlhokahalong ea 'maraka, tsoelo-pele ea theknoloji ea li-peptide tse nyane, le litlhoko tsa boleng, le mekhoa e meng ea sejoale-joale,' me e fana ka maikutlo a tsela e tala ea phetoho ea leruo la liphoofolo ka 2025.
1. Mekhoa ea maano
1) EU e ile ea kenya ts'ebetsong ka molao Molao oa Phokotso ea Phaello ea Liphoofolo ka Pherekhong 2025, e hlokang phokotso ea 30% ea masala a tšepe e boima ho fepa, le ho potlakisa phetoho ea indasteri ho likarolo tsa organic trace. 2025 Green Feed Act e hloka ka ho hlaka hore ts'ebeliso ea lintho tse sa bonahaleng (tse kang zinc sulfate le copper sulfate) phepelong e fokotsoe ka 50% ka 2030, le hore lihlahisoa tsa chelated tsa organic li khothaletsoe e le tsona tse tlang pele.
2) Lekala la Chaena la Temo le Litaba tsa Mahaeng le ile la lokolla "Green Access Catalog for Feed Additives", 'me lihlahisoa tse nyenyane tsa peptide chelated li thathamisitsoe e le "mekhoa e meng e khothalletsoang" ka lekhetlo la pele.
3) Asia Boroa-bochabela: Linaha tse ngata li ile tsa thakhola ka kopanelo "Leano la Temo la Zero Antibiotic" ho khothaletsa ho sala morao likarolo ho tloha ho "tlatsetso ea phepo" ho ea "taolo ea ts'ebetso" (joalo ka anti-stress le matlafatso ea 'mele ea ho itšireletsa mafung).
2. Liphetoho tlhokahalong ea 'maraka
Keketseho ea tlhokahalo ea bareki ea "nama e nang le masala a lithibela-mafu" e tsamaisitse tlhokahalo ea likarolo tsa ho latela tikoloho tse nang le litekanyetso tse phahameng tsa ho monya ka lehlakoreng la temo. Ho latela lipalo-palo tsa indasteri, boholo ba 'maraka oa lefats'e oa likarolo tse nyane tsa peptide chelated trace e eketsehile ka 42% selemo le selemo ho Q1 2025.
Ka lebaka la maemo a leholimo a feteletseng khafetsa Amerika Leboea le Asia Boroa-bochabela, mapolasi a ela hloko haholo karolo ea likarolo tsa trace ho hanela khatello ea maikutlo le ho matlafatsa sesole sa liphoofolo.
3. Katleho ea theknoloji: tlholisano ea mantlha ea lihlahisoa tse nyane tsa peptide chelated trace
1) Bioavailability e sebetsang hantle, e phunyeletsang botlolo ea ho monya ha setso
Li-peptide tse nyane li chelate ho latela likarolo ka ho phuthela li-ion tsa tšepe ka liketane tsa peptide ho etsa li-complexes tse tsitsitseng, tse kenngoang ka mafolofolo ka har'a tsamaiso ea mala ea peptide (joalo ka PepT1), ho qoba tšenyo ea gastric acid le antagonism ea ion, mme bioavailability ea tsona e phahame ka makhetlo a 2-3 ho feta ea matsoai a inorganic.
2) Synergy e sebetsang ho ntlafatsa ts'ebetso ea tlhahiso ka litekanyo tse ngata
Likarolo tse nyane tsa peptide li laola limela tsa mala (libaktheria tsa lactic acid li ata ka makhetlo a 20-40), li ntlafatsa nts'etsopele ea 'mele oa ho itšireletsa mafung (antibody titer e eketseha ka makhetlo a 1.5), le ho nolofatsa ho monya limatlafatsi (karolelano ea lijo le nama e fihla ho 2.35: 1), ka tsela eo e ntlafatsa ts'ebetso ea tlhahiso maemong a mangata (+ 48%) le boima ba letsatsi le letsatsi (+ 48%).
3) Botsitso bo matla, bo sireletsang boleng ba phepo ka katleho
Li-peptide tse nyane li theha khokahano ea meno a mangata le li-ion tsa tšepe ka li-amino, carboxyl le lihlopha tse ling tse sebetsang ho theha sebopeho sa ringchelate sa litho tse hlano / tse tšeletseng. Khokahano ea selikalikoe e fokotsa matla a sistimi, tšitiso ea steric e sireletsa tšitiso ea kantle, 'me ho se nke lehlakore ha tefiso ho fokotsa repulsion ea electrostatic, eo hammoho e matlafatsang botsitso ba chelate.
| Li-constants tsa botsitso tsa li-ligands tse fapaneng tse tlamang li-ion tsa koporo tlas'a maemo a tšoanang a fisioloji | |
| Ligand Stability kamehla 1,2 | Ligand Stability kamehla 1,2 |
| Log10K[ML] | Log10K[ML] |
| Li-amino Acids | Tripeptide |
| Glycine 8.20 | Glycine-Glycine-Glycine 5.13 |
| Lysine 7.65 | Glycine-Glycine-Histidine 7.55 |
| Methionine 7.85 | Glycine Histidine Glycine 9.25 |
| Histidine 10.6 | Glycine Histidine Lysine 16.44 |
| Aspartic acid 8.57 | Gly-Gly-Tyr 10.01 |
| Dipeptide | Tetrapeptide |
| Glycine-Glycine 5.62 | Phenylalanine-Alanine-Alanine-Lysine 9.55 |
| Glycine-Lysine 11.6 | Alanine-Glycine-Glycine-Histidine 8.43 |
| Tyrosine-Lysine 13.42 | Qotsulo: 1.Stability Constants Qeto le Tšebeliso, Peter Gans. 2. Li-constants tse khethiloeng ka mokhoa o tsitsitseng oa lisebelisoa tsa tšepe,NIST Database 46. |
| Histidine-methionine 8.55 | |
| Alanine-Lysine 12.13 | |
| Histidine-serine 8.54 | |
Setšoantšo sa 1 Li-constants tsa botsitso tsa li-ligands tse fapaneng tse tlamang ho Cu2+
Mehloli e sa sebetseng hantle ea liminerale e na le menyetla ea ho ba le maikutlo a redox ka livithamini, oli, li-enzyme le li-antioxidants, tse amang boleng bo sebetsang ba limatlafatsi tsa phepo. Leha ho le joalo, phello ena e ka fokotsoa ka ho khetha ka hloko ntho ea trace e nang le botsitso bo phahameng le karabelo e tlaase ka livithamine.
Ho nka livithamine e le mohlala, Concarr et al. (2021a) o ile a ithuta botsitso ba vithamine E ka mor'a ho boloka nako e khutšoanyane ea inorganic sulfate kapa mefuta e sa tšoaneng ea organic mineral premixes. Bangoli ba fumane hore mohloli oa li-trace elements o ile oa ama haholo botsitso ba vithamine E, 'me premix e sebelisa organic glycinate e na le tahlehelo e phahameng ka ho fetisisa ea vithamine ea 31.9%, e lateloa ke premix e sebelisang li-amino acid complexes, e neng e le 25.7%. Ho ne ho se na phapang e khōlō ea tahlehelo ea botsitso ea vithamine E ho premix e nang le letsoai la protheine ha e bapisoa le sehlopha sa taolo.
Ka mokhoa o ts'oanang, tekanyo ea ho boloka li-vithamine ho li-organic trace element chelates ka mokhoa oa li-peptide tse nyenyane (tse bitsoang x-peptide multi-minerals) li phahame haholo ho feta tsa mehloli e meng ea liminerale (Setšoantšo sa 2). (Hlokomela: Liminerale tse ngata tsa organic setšoantšong sa 2 ke letoto la liminerale tse ngata tsa glycine).
Setšoantšo sa 2 Phello ea li-premixes tse tsoang mehloling e fapaneng ka sekhahla sa ho boloka livithamine
1) Ho fokotsa tšilafalo le mesi ho rarolla mathata a tsamaiso ea tikoloho
4. Litlhoko tsa boleng: maemo le ho lumellana: ho nka sebaka se phahameng sa tlhōlisano ea machaba
1) Ho ikamahanya le melaoana e mecha ea EU: kopana le litlhoko tsa melaoana ea 2024/EC le ho fana ka limmapa tsa litsela tsa metabolic.
2) Theha matšoao a tlamang le sekhahla sa chelation sa label, khafetsa ea ho arohana, le litekanyetso tsa botsitso ba mala.
3) Khothaletsa theknoloji ea polokelo ea bopaki ba blockchain, litekanyetso tsa ts'ebetso ea ho kenya le litlaleho tsa liteko nakong eohle ea ts'ebetso
Theknoloji e nyane ea peptide trace element ha se phetoho feela ho li-additives tsa lijo, empa hape ke enjine ea mantlha ea phetoho e tala indastering ea liphoofolo tse ruiloeng. Ka 2025, ka ho potlakisa ha digitalisation, scale le internationalization, thekenoloji ena e tla fetola tlhōlisano ea indasteri ka litsela tse tharo tsa "ntlafatso ea katleho-tšireletso ea tikoloho le phokotso ea boleng-e ekelitsoeng". Nakong e tlang, hoa hlokahala ho matlafatsa tšebelisano-'moho pakeng tsa indasteri, thuto le lipatlisiso, ho khothalletsa ho ikopanya ha lichaba tsa maemo a theknoloji, le ho etsa hore tharollo ea Chaena e be letšoao la tsoelo-pele e tsitsitseng ea mehlape ea lefatše.
Nako ea poso: Apr-30-2025
